Beta-ecdysterone anabolic environment enhancer

As for mechanisms of action, ecydsteroids seem to be able to cause a rapid Ca2+ influx in myocytes which leads to phosphorylation of Akt and thus protein synthesis. [1] This effect occurs after 10s of incubation, and is inhibited by PI3K inhibitors like seen in other studies, but also GPRC and PLC inhibitors; and when the cells are depleted of intra-cellular calcium Akt does not get phosphoraylized, and binding free calcium with EGTA lowered protein synthesis from 16% to 8%. [1] Calcium per se can be an important mediator of Akt and protein synthesis [51] , and ecdysteroids seem to work vicariously through Ca2+ and Akt. [52]

Beta-ecdysterone anabolic environment enhancer

beta-ecdysterone anabolic environment enhancer

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